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Comparing Pfizer with AstraZeneca  Rate Topic 
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 Posted: Mon Feb 22nd, 2021 06:25 pm
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asjogren
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A large cohort study out of Scotland shows some interesting results.  The study period is December 8 - 15 February.  1.2 million people.  Remember the people being vaccinated are front line health care workers, elderly care residents and workers, and the oldest section of Scottish society.  These are the most likely to be hospitalized.


The study begins 4 weeks after the first dose.  The current UK protocol is to prioritize first dose and delay second for 12 weeks. So, this primarily is about first dose.


Pfizer showed 84% reduction in hospitalizations after 4 weeks.  There were 690,000 people in this study group.


AstraZeneca showed 94% reduction in hospitalizations.  There were 490,000 people in this study group.


It is interesting that the efficacy of AstraZeneca was significantly less than Pfizer in the clinical trials, but in this study AstraZeneca was a bit better at reducing hospitalizations.  Note that these are two different metrics.  The clinical trial of Pfizer measured symptomatic disease.  The clinical trial of AstraZeneca measured both symptomatic and asymptomatic disease.  And in this new study hospitalizations were the metric of interest.


This data is coming from anonymized National Health Service data.  They knew some person was vaccinated on a particular date with a specific vaccine and they could tell of that same person was later hospitalized.  They did not know who exactly that person was.  They were precluded from discovering that in order to get access to the data.

Last edited on Tue Feb 23rd, 2021 01:44 am by asjogren

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 Posted: Mon Feb 22nd, 2021 11:44 pm
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Bullshipper
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They are saying that they are srprised that Astra actually works better with one shot than two aren't they?

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 Posted: Tue Feb 23rd, 2021 01:15 am
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nice guy
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I don't think we're going to get a choice. I didn't get a menu when I registered here.

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 Posted: Tue Feb 23rd, 2021 01:49 am
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asjogren
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What was surprising about AstraZeneca was that lengthening the time between doses significantly increased efficacy.

Sputnik V got around this by using different AdenoVirus delivery mechanisms in dose 1 versus dose 2.

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 Posted: Tue Feb 23rd, 2021 02:09 am
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asjogren
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The reason I posted this comparison is that many articles are implying that AstraZeneca is not worth getting. South Africa even stopped their vaccination program using AstraZeneca because of reduced efficacy against the B.1.351 variant. South Africa had already bought it and had it delivered.

Efficacy is NOT the only metric worth noting. In fact efficacy is difficult to compare. For example, Pfizer and Moderna measured only symptomatic disease to compute efficacy. They waited for symptoms and then tested. AstraZeneca measured the sum of symptomatic plus asymptomatic disease. AstraZeneca tested everyone each week. Are those efficacy numbers directly comparable? No way.

My point is that ALL these have shown significant benefit. ALL show great benefit in avoiding severe disease. Avoiding the hospital.

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 Posted: Wed Feb 24th, 2021 01:03 am
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Hook
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What is suspect is the subjective decision, made by many different doctors, as to whether a person needs to be "hospitalized" or not. That variable needs to be standardized, if it hasn't already been. Any indication of this?

Maybe it's not enough to sway the results one way or another, I dont know.

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 Posted: Wed Feb 24th, 2021 03:34 am
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asjogren
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I do not know what differences there are between doctors in Scotland regarding hospitalization decisions for Covid-19. However, I strongly suspect that since Scotland has a national health service that these decisions are reasonably standardized. Since this is a nation wide study those individual differences should cancel out. The number of people in the study is 1.2 million. It is not a small study.

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 Posted: Wed Feb 24th, 2021 02:13 pm
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Bullshipper
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JJ only 62% effective, on eariier strains approved yesterday for use

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